In contrast, when micafungin-treated cultures were observed by SEM, three prominent types of change in hyphal morphology were produced: (i) formation of numerous short branches on the lateral walls; (ii) distortion and collapse of whole hyphae; and (iii) disruption of tips of both hyphae and lateral branches. Although such types of hyphal change were similarly seen in all micafungin-treated cultures, whatever the concentration (0.001, 0.01 and 0.1 mg ml—1), the changes became more intense and frequent with increasing drug concentration and length of treatment time.