Conclusion The nanoemulsion developed in this study using the phase diagram method was composed of 10% rice bran oil, 10% surfactants sorbitan oleate/PEG-30 castor oil, 0.05% antioxidants and 0.50% preservatives formulated in distilled water. The nanoemulsion was stable during the period of study and was found to be practically non-irritating in the organotypic HET-CAM model. When applied to the skin of volunteers, the nanoemul- sion increased the relative hydration of the skin, the
skin oiliness and maintained normal skin pH values. This nanoemulsion could serve as an alternative treat- ment for skin diseases such as atopic dermatitis and psoriasis.