A genetic approach also offers novel methods
to explore potential mechanisms linking shorter
height with an increased risk of CAD (Fig. 3). In
this context, we performed two analyses. First,
we applied the same genetic approach to investigate
the association between height-related
genetic variants and several established and potential
cardiovascular risk factors. Notable negative
findings here include the lack of an overall
effect of height-associated SNPs on body-mass
index. This suggests that the association between
shorter stature and an increased risk of
CAD is not mediated by an effect on obesity. On