The present study was carried out to examine whether parameters of oxidative stress are also found in β-thalassemia/Hb E patients and whether they can be ameliorated following treatment with the extract derived from dried rhizomes of curcumin (Curcuma longa Linn) also known as turmeric, a natural herb being used as food additive or traditional medicine for centuries. Curcumin extract is non-toxic to animals or humans, even at high doses and the National Cancer