On the other hand, a hot, aqueous infusion solubilizedonly 0.213% of the annonacin and too little of the squamocin to be detected. So, graviola leaves containsignificant amounts of the neurotoxins annonacin and squamocin, as well as some potentially healthyphenolic compounds. Finally, the potential neurotoxicity of whole leaves in dietary supplements couldbe much higher than that of a tea (hot aqueous infusion) that is made from them.