He will rack up 1,635 nautical miles, equal to nearly 1,900 land miles (3,000 kilometres) over the course of the journey, while taking in up to 12,000 calories a day.
Hooper's journey will be observed by a Guinness World Records representative who will join a crew of 10 supporting the swimmer.
His crossing will be filmed and can be tracked on his "Swim the Big Blue" website.