To evaluate the antihemorrhagic activity of the Combretum
leprosum extract and arjunolic acid,three different protocols were
used:preincubation: Bothrops jararaca venom dissolved in PSSwas
first in cubated with the extract(10or100mg/kg)or arjunolic acid(3
and 30mg/kg) for 15min at room temperature prior to injection;
pretreatment:0.2mL of arjunolic acid(3 and 30mg/kg)was
administered orally 30min before the intradermic(i.d.)venom
injection; post-treatment:0.15mL of arjunolic acid(30mg/mL)
was administered i.p.5min after the intradermic (i.d.)venom
injection.