Nicotinamide is a GRAS status co-crystallizing compound. It is a primary amide with two
hydrogen bond donors (NH2) and an acceptor (C=O), demonstrate a remarkable ability to form hydrogen bonds for the formation of an intermolecular drug molecule: co-crystal former synthon. A second hydrogen bond acceptor is the lone pair on the N atom of the pyridine ring (12). This makes the molecule very versatile for a variety of hydrogen bonded interactions which makes Nicotinamide to be excipient of choice.