Cadmium (Cd) is one of the heavy metal that has been used extensively as a material in the agriculture and chemical industry such as inorganic fertilizers, pesticides, paintings, etc., and it can be released into the soil and water. Cd contamination in agricultural soils is unlikely to affect plant growth, but Cd is easily transferred to human food chains from the soils. Moreover, an excess of toxic heavy metal ions induces several cellular stress responses and damage to different plant cellular components such as membranes, proteins and DNA (Manahan, 2003; Liu et al., 2005). Ipomoea aquatica is one of the popular vegetables in northeastern Thailand, and other Asian countries. The aims of this study were to determine the contents of Cd in different tissues, viz. roots, stems, and leaves, and to detect DNA damage in the plant induced by Cd using random amplified polymorphic DNA (RAPD) markers.