Research on strategies to inhibit these deleterious aspects of the post-ischaemic inflammatory
reaction might therefore very well come to fruition with attractive new clinical therapies with
a potentially wide therapeutic window. On the other hand, post-ischaemic inflammation has also
demonstrated beneficial effects as, for example, in the context of ischaemic tolerance (IT) and tissue
repair. IT in the brain describes the phenomenon of a transient state of increased resistance to a lethal
ischaemic challenge that ensues when a sublethal damaging stimulus is applied in a timely manner
before the lethal insult.63,64