Patients with type 2 diabetes are at higher risk of fungal genital infections and UTIs compared with the general population (19). Dapagliflozin-treated patients, especially women, reported an increase in events suggestive of genital infections and lower UTIs compared with glipizide-treated patients. For conservative pharmacovigilance purposes with
this first-in-class agent, events suggestive of genital infection and UTI were reported spontaneously and in response to questions proactively posed to patients that were related to the signs and symptoms of these infections. Not all of these suggestive events could be confirmed as infections (Table 1). Variable reports of these events have been noted in previous studies with dapagliflozin (13,18,20,21); hence, further analyses using pooled data are required to better evaluate potential risk factors for genital and UTIs with SGLT2 inhibitors such as dapagliflozin.
Patients with type 2 diabetes are at higher risk of fungal genital infections and UTIs compared with the general population (19). Dapagliflozin-treated patients, especially women, reported an increase in events suggestive of genital infections and lower UTIs compared with glipizide-treated patients. For conservative pharmacovigilance purposes withthis first-in-class agent, events suggestive of genital infection and UTI were reported spontaneously and in response to questions proactively posed to patients that were related to the signs and symptoms of these infections. Not all of these suggestive events could be confirmed as infections (Table 1). Variable reports of these events have been noted in previous studies with dapagliflozin (13,18,20,21); hence, further analyses using pooled data are required to better evaluate potential risk factors for genital and UTIs with SGLT2 inhibitors such as dapagliflozin.
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