To explore the detailed mechanism which may play an important
role in this process, several genes which were found to be downregulated
by baicalein as measured bymRNA array (data not shown), including
Aquaporin 1 (AQP1), CD24, Claudin-10 (CLDN10), Collagen type I
alpha1 (COLIA1), Dickkopf-related protein 3 (DKK3), GTP-binding protein
(GEM) and Lumican (LUM) were confirmed by RT-PCR (Fig. 3A).