The results of this study indicate that dietary quillaja saponins enhance the immune function of the weanling pig in normal commercial rearing situations in the absence of any controlled pathogen challenge. Dietary saponins also increased piglet feed intake; however, no benefit to growth was observed, resulting in lower feed efficiency. The use of controlled enteric disease challenge would allow better assessment of the ability of saponin to potentiate piglet immune function and promote piglet health. Conversely, curcumin offered in the diet did not influence piglet performance or measures of immune function in the immediate postweaning period.