Due to the complex and distributed nature of high-end projects in Life Science Automation, it is still not possible to simulate workflows on laboratory workbenches frequently in a real time equivalent manner. It is crucial to ensure the availability of desired assays and automated workflows in advance. This paper presents the concept of a 4D simulation system, which synthesizes technologies as Process Control Software (PCS), Data Management System (DMS), programming technology, advanced CAD technology and some 3D animation tool to realize a dynamic simulation for Laboratory Workflow Management. The system would be flexible and controllable for automation assays, improve laboratory workflows, efficiency and accuracy, which would reduce the assays cost and the risks of rushing to unreasonable plans, and also improve the laboratory management level.