Thus, it presents a promising strategy for the treatment
of influenza A virus, particularly for severe and immunocompromised
patients. A combination of amantadineþoseltamivir as well as
favirpiravirþoseltamivir have demonstrated enhanced drug effi-
cacy in H5N1 infected mice. Recently, combination therapy with
three antiviral drugs (amantadine, ribavirin, and oseltamivir) in
patients with severe A/H1N1 2009 (pH1N1) influenza in Korea has
reduced the 14-day mortality. In another study, triple-combination
antiviral drug therapy showed similar pharmacokinetics to mono-drug
therapy and demonstrated increased safety in immunocompromised
patients. Currently, several combination therapies based on
approved and/or new drugs are under investigation.