Abstract Crowberry (Empetrum nigrum L.) is a wild berry commonly found in the northern
hemisphere. Crowberry fruits have been suggested as good resources for functional applications
in the cosmetic and pharmaceutical industries, but the high polyphenolic content in crowberry
leaves also indicates crowberry aerial parts as potential dietary health supplements. In this study,
therefore, the biological activities of the aerial parts of Korean crowberry (E. nigrum var.
japonicum) were investigated. Antioxidant activity was measured by three different assays on DPPH
free radical scavenging, reducing power, and total antioxidant capacities. Dose-dependent antioxidant
activities were exhibited by crude methanol extract and its fractions, suggesting that the crude
methanol extract and EtOAc fraction possessed strong antioxidant activities and capacities. In
addition, the crude methanol extract and EtOAc strongly inhibited a-glucosidase activity and suppressed
the secretion of pro-inflammatory mediator and nitrite oxide from LPS-stimulated RAW
264.7 cells. These findings provide valuable evidence for the potential of such parts as good dietary
Abstract Crowberry (Empetrum nigrum L.) is a wild berry commonly found in the northernhemisphere. Crowberry fruits have been suggested as good resources for functional applicationsin the cosmetic and pharmaceutical industries, but the high polyphenolic content in crowberryleaves also indicates crowberry aerial parts as potential dietary health supplements. In this study,therefore, the biological activities of the aerial parts of Korean crowberry (E. nigrum var.japonicum) were investigated. Antioxidant activity was measured by three different assays on DPPHfree radical scavenging, reducing power, and total antioxidant capacities. Dose-dependent antioxidantactivities were exhibited by crude methanol extract and its fractions, suggesting that the crudemethanol extract and EtOAc fraction possessed strong antioxidant activities and capacities. Inaddition, the crude methanol extract and EtOAc strongly inhibited a-glucosidase activity and suppressedthe secretion of pro-inflammatory mediator and nitrite oxide from LPS-stimulated RAW264.7 cells. These findings provide valuable evidence for the potential of such parts as good dietary
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