Hydralazine has little
value in the management of chronically elevated BP in CKD,
although it is sometimes used as a parenteral hypotensive
agent. Minoxidil is generally used in patients with very
resistant hypertension and thus may be helpful in patients
with CKD. However, its side effects (e.g., severe fluid
retention, headache, tachycardia, hirsutism, and pericardial
effusion) limit its use to the most resistant cases