The disorders of iron overload due to primary or secondary cause are one of the important human diseases
leading to high mortality if untreated. To understand this, an animal model has been extensively studied. The
source of iron administered to the mode of iron administration that can mimic the iron overload in humans
has been studied. A safe and orally active iron chelator is still needed as many of the existing compounds have
different types of complications and toxicity associated. Hence having a simple animal model which can be
availed quickly and can be used to study various compounds for its iron chelating activity would likely to have
immense utility for pharmacological studies. In this review we have shown how, using a simple procedure, a
large number of small iron overloaded animals can be produced easily for various studies.