Curcuma phaeocaulis Valeton power was extracted
with ethanol and the main components of the extract (Cpv) were analyzed with HPLC. The effect of
Cpv on MCF-7 cells proliferation, intracellular reactive oxygen species (ROS) formation, mitochondrial
membrane potential (m), apoptosis, apoptotic related proteins, MDA-MB-231 cell migration, and
integrins expression were determined.
Furthermore, the effect of Cpv on some key signal transduction
molecules was also investigated. Furanodienone, germacrone and furanodiene were identified as the
main components of Cpv