Paradoxically, both HA and the enzymes that eliminate HA, hyaluronidases, can correlate with cancer
progression. It has been shown that the over expression of hyaluronic acid synthases increases the HA
level, which leads to the acceleration of tumor growth
and metastasis. On the other hand, exogenous oligometric HA inhibits tumor progression, most likely by
competing with endogenous polymeric HA