Free radical theory strengthens the hypothesis that ageing occurs
by the accumulation of oxidative damage, such as DNA mutation, and
lipid and protein dysfunction. Epidemiological research reveals that
the consumption of antioxidant phytochemicals shows benefits for
oxidative stress-induced damage [21]. Herein, we investigated
whether supplementation of mulberry extracts (ME), which is rich
in nutraceuticals including phenolic compounds and flavonoids, could
protect the liver from age-associated antioxidant decline and protect
the brain from cognitive deficits in SAMP8 mice. The antioxidant
capacity of the liver and brain was evaluated, and the serum
biochemical values were examined. Moreover, the signal transduction
molecules involved were also discussed.