Acupuncture for treatment of musculoskeletal disorders is growing in acceptance by both physicians and patients. It is one of the best recognized complementary and alterna-tive medical treatments. Although the classical explanation of acupuncture’s method of action has been a change in the Qi or energy flow of the body, many studies have proposed different mechanisms of action. Local effects include dilatation of blood vessels, distortion of the connective tissue, and changes in regional autonomic activity. The remote endocrine effects consist of release of endorphins and neurologic effects such as alterations on functional magnetic resonance imaging of the brain can also occur. Several pathways of anti-inflammatory actions are also mentioned [15,16].