this study revealed that two electronic cigarette
brands do not expose electronic cigarette–naïve users to nicotine
or carbon monoxide under the acute testing procedures
described here, but do produce some tobacco
abstinence symptom suppression and positive ratings of
product acceptability. Although these results are necessarily
a function of the products tested and procedures used, they
suggest that electronic cigarette–naïve individuals may require
substantial motivation if they are to learn whatever
product/procedure combination maximizes these outcomes
for them. Future clinical laboratory evaluation can build on
these methods and results to establish the extent to which
electronic cigarettes might be expected to substitute for tobacco
cigarettes, and help to identify under what conditions
this substitution might occur. Parallel studies addressing the
abuse liability and long-term adverse event profile of electronic
cigarettes are also required to ensure safety and appropriate
labeling and marketing of these products.