Increased levels of miR-196a have also been found in 12
cancer cell lines of oesophageal, breast and endometrial origin
and 10 oesophageal adenocarcinomas; furthermore, levels of
miR-196a have been demonstrated to have a significant inverse
correlation with annexin A1 mRNA levels in these cancers [40].
Annexin A1 has been postulated to act as tumour suppressor in
different cancers such as prostate, breast, oesophageal and B-cell
non-Hodgkin’s lymphoma [63–67]. As annexin A1 could be a target
molecule of miR-196a, increased miR-196a may mediate
down-regulation of annexin A1, contributing to tumorigenesis.