The wide application of evaporative cooling techniques in which the optimization criteria form the theoretical basis for improving
evaporative cooling performance is essential for energy conservation and emission reduction. Based on exergy analysis and the
entransy dissipation-based thermal resistance method, this contribution aims to investigate the effects of flow and area distributions
in the optimization of the performance of indirect evaporative cooling systems. We first establish the relationships of exergy
efficiency, entransy dissipation-based thermal resistance and cooling capacity of a typical indirect cooling system. Using the prescribed
inlet parameters, the heat and mass transfer coefficients and the circulating water mass flow rate, we then numerically
validate that when the cooling capacity reaches a maximum, the entransy dissipation-based thermal resistance falls to a minimum
while the exergy efficiency is not at an extreme value. The result shows that the entransy dissipation-based thermal resistance, not
the exergy efficiency, characterizes the heat transfer performance of an evaporative cooling system, which provides a more suitable
method for evaluating and analyzing the indirect cooling system.