Animal
Eight-week-old male ICR mice were purchased from Orientbio (Seongnam, Korea) to be used for an ear edema test. Ten-week-old female Balb/c mice were used for acute toxicity test. Mice were preliminarily bred in an animal room where the temperature of 20 ± 2 °C, the humidity of 50 ± 10%, and a 12/12-h light–dark cycle were maintained for a week to be used in tests.