3.1.2. PTB
Twenty-eight studies evaluated the association between antenatal
antidepressant exposure and PTB with RRs ranging from 0.40 to 11.70
(Table 2). Using the random-effects model, antenatal antidepressant
exposure was significantly associated with PTB (RR: 1.69, 95% CI:
1.52–1.88). Nine of the studies found no significant association.
Significant heterogeneity across studies was noted (Q27=49.4; P=