3. ReAmong the 339 targets, 22 targets are classified as outliers, and the remaining 317 targets are analyzed. Original RMSD data are fitted to a rational function as the RMSD gradually decreases with increasing sequence identity of the best template. The targets with larger RMSD than two times of the fitting curve value are assigned as outliers (Figure S2). Many outliers have multiple domains or no proper structure molds (Table S1). A detailed discussion of these cases is in the Supporting Information. sults and discussion