the SC of the skin. Based on inherent barrier properties, the SC inhibits transdermal delivery of hydrophilic and large molecular weight molecules [10,11]. The plasma membrane of the cell is mainlycomposedofvarioustypesofphospholipidsandmembrane proteins. The membrane proteins transport hydrophilic and larger uncharged polar molecules (such as glucose and ions) across membrane. However, organic compounds such as OA and EtOH are chemical enhancers that can alter the packing structure of the SC lipids to increase lipid fluidity and reduce skin resistance [12,13].A better understanding of the transdermal delivery of ZnO NPs via chemically enhanced pathways may optimize the applications and address biocompatibility issues of NPs in the SC.