The wrinkle grades (the decrease from baseline) in the tested site significantly improved at 4 and 8 weeks as compared with pretreatment (P < 0.001). The control site also showed significant improvement at 4 and 8 weeks as compared with pre-application (P < 0.01). The tested site showed significant reduction as compared with the control site both at 4 and 8 weeks (P < 0.001) (Fig. 1). Representative cases with marked response are shown in Figures 2 and 3.