AP propagation, is affected by external RF-induced cur- rents circulating on the cellular membrane. The message generated by a neuron is encoded with a spike train, charac- terized by firing rate, spike amplitude and inter-spike corre- lation. Alteration of the AP firing after an external action on the membrane potential, e.g., RF exposure, could give rise to incorrect message propagation through the whole or- ganism with unpredictable consequences on biological and cognitive function. To the best of our knowledge, few ef- forts have been spent in a theoretical description of the possible interaction between RF technologies and neuronal sytems. Among the others, proteins membrane mechanisms were studied in [5], demonstrating that protein channels are sensitive to EM field exposure while in [8] (1978) the authors propose a mathematical explanation of the shift in cellular resting potential originated by microwave induced currents. More recently, [1] investigated the biological effects experi- enced after EM field exposure generated by mobile commu- nication devices. In this paper we propose an alternative modeling concept which integrates the main ingredients of neuron modeling and the EM field characteristics in a unified model. Basically, we can identify the following operational steps: