Control group – only water feeding for 4 weeks (negative control).
SME group – SME administered orally at 200 mg/kg bw for
4 weeks (positive control).
STZ group – single injection of STZ at 50 mg/kg bw and water feeding for 4 weeks.
STZ + SME group – oral administration of SME at 200 mg/kg bw for 4 weeks after a single injection of STZ at 50 mg/kg bw.
SME + STZ group – single injection of STZ at 50 mg/kg after oral administration of SME at 200 mg/kg bw for 2 weeks.
Water + STZ group – single injection of STZ at 50 mg/kg bw after water feeding for 2 weeks.