DEC1 might be involved in the generation and regulation of the side effects induced by quinolones. DEC1 expression disturbed by quinolones might disrupt the equilibrium of protein–protein interactions in the affected cells and subsequently lead to biological disorder. Investigation of the molecular details of the toxicity may help overcome the shortcomings of quinolones and reveal new, useful therapy functions besides the antimicrobial effects. Meanwhile, knowledge of the protective mechanisms of DEC1 may provide insight into new therapeutic strategies in tumors and
metabolic and immunological disease.