Photocarcinogenesis is caused by DNA damage to the skin
from solar radiation in the ultraviolet range and resulting in
the development of both melanoma and nonmelanoma skin
cancers. Curcumin has been shown to protect against the deleterious
effects of injury by attenuating oxidative stress and
suppressing inflammation [64]. Curcumin block multiple targets
of these pathways and can be used in the chemoprevention
of photoaging skin and photocarcinogenesis. Curcumin not
only activates caspase-3 and caspase-8 in human melanoma
cell lines, it also induces activation of a death receptor pathway,
by inducing Fas receptor [64].