This research applied Data Mining techniques to extract knowledge from student database of Prince of Songkla University, Trang Campus and to create academic performance prediction for freshmen in the first semester. This research is to be a guideline for planning and decision-making in student enrollment and education management. The data used in the work include student profiles and student grades. Three main approaches were used in this research including the Decision tree, Associated Rules, and Clustering by using WEKA v.3.6.10 as a tool. Finally, this research show that the result models obtain 80% of accuracy rate.