On August 1, 2016, CDC issued guidance for people living in or traveling to a 1-square-mile area of the Wynwood neighborhood in Miami, FL, identified by the Florida Department of Health as having mosquito-borne spread of Zika. On August 19, CDC also issued guidance for a 1.5-square-mile section of Miami Beach identified to have mosquito-borne spread of Zika; on September 17, this section was expanded to a 4.5-square-mile area.
On September 19, CDC updated guidance for the Wynwood-designated area after three mosquito incubation periods passed without any new locally transmitted cases of Zika.
On October 13, Florida announced a new area of mosquito-borne spread of Zika in an additional 1-square-mile area in Miami-Dade County, FL. Because local spread of Zika virus continues to be reported in Miami-Dade County, CDC updated its travel and testing guidance on October 19 to apply recommendations to all of Miami-Dade County.