2.4 Zong et al. [7] proposed developed a tool for the identification of different white blood cell categories in a given blood sample Two approaches were implemented with two different parametric data clusters. In the first, multidimensional space using artificial neural networks (ANNs) was trained followed by cross-validation using cytometry data. The second approach exploited gene expression profiling of ALL to classify its six subtypes. The system was also trained to assess the inherent problem of data overlap and to recognize abnormal blood cell patterns. The classification performance of the first approach reached up to 100% while the performance of the second approach was up to 92%.AnovelANNalgorithm for optimizing the classification of multidimensional data, which focused on acute leukemia