Selenium and vitamin E as the minerals and vitamins that have a relationship to antioxidant activity, treatment of various tissues and to encourage immune Response. Supplementation with selenium and vitamin E did not direct effect on productivity, but it could increased immune system and reduce disorder in dairy cattle. Moreover, selenium has important role on treatment and prevention diseases of mammary gland as well as reduce somatic cell in milk. In conclusion, selenium and vitamin E supplement could enhance prevention and treatment of disorders in prepartum and pospartum dairy cow with resulted in a good health and creased productivity