AbstractAbstract
Background: Cow’s milk protein allergy (CMPA) is being seen more frequently on a daily basis
in pediatric consultations. It shares symptoms with gastroesophageal reflux (GER), which can
complicate the differential diagnosis.
Aims: To attempt to corroborate the presence of acid GER in children with CMPA, as well as to
find a characteristic profile through the 24-hour pH monitoring study in children with GER and
CMPA
Methods: The intraesophageal pH monitoring studies performed on 47 children with CMPA were
reviewed. The measurements in all the studies were carried out within a 24-hour period using
Digitrapper® equipment with a multi-use GeroFlex® catheter, after calibration with pH 7 and
pH 1 buffer solutions.
Results: Of the 47 children, 23 were boys (32.4%) and 24 were girls (33.8%) and the mean age
was 5 ± 3.7 years. Fourteen of the 47 children (29%) presented with GER, according to the result
of the 24-hour intraesophageal measurement. Only 2 of the 47 patients studied fit the phasic
profile.
Conclusions: The findings show the existing relation between the two pathologies. Nevertheless,
it is important to determine the presence of non-acid or weak acid reflux, because their
existence can increase this association.