Excessive and sustained activation of the endothelium resulting
in increased vascular permeability is a crucial process during sepsis.The septic syndrome is characterized by a systemic inflammatory response in the effort of the organism to eliminate/control
infections. A common element of severe infections is the very acute, potent and generalized activation of the immune and hemo-static system. This may result in extensive inflammation and
vascular thrombosis, a microcirculatory disorder that has as a consequence the disruption of smooth blood flow and hence oxygen toward the cells