Postweaning piglets commonly suffered morphology atrophy and crypt hyperplasia that could limit the absorp- tion of voluntary feed intake and weight gain after weaning (Loh et al. 2002; Hedemann et al. 2003). Measurement of intestinal villus height and crypt depth was determined for the surface area of intestine undertaken for nutrient absorption. The present results showed that metabolite combinations did not affect the crypt depth of piglets after receiving different treatments for 5 weeks. However, the duodenal villus height was higher in Com 2 treatment compared to the −ve control group, indicating the feeding of metabolite would improve the height of villus, particu- larly at the duodenum. The development in villus height at different segments of small intestine might be attributed to the role of the intestine epithelium as a natural barrier (Paul et al. 2007).