Based on a review of evidence, the University of Colorado Hospital CAUTI Interdisciplinary Quality Intervention Team initiated a quality improvement project that provided a multifaceted nursing-driven approach to reduce CAUTIs. Our hospital was not using physician order entry; consequently, using electronic charting systems to provide question prompts or decision trees to validate the need for an indwelling bladder catheter as well as automatic stop orders were not available. The purpose of this quality improvement process study was to develop and implement evidence-based, multifaceted, nurse-driven interventions to improve urine elimination management in hospitalized patients and to measure the impact of these interventions on the duration of indwelling urinary catheterization (dwell time) and the CAUTI incidence among patients on the target inpatient units.