In 1921, Frederick Grant Banting and Charles Herbert
Best repeated the work of Von Mering and Minkowski
but went a step further and managed to show that they
could reverse the induced diabetes in dogs by giving
them an extract from the pancreatic islets of
Langerhans of healthy dogs. This was a step forward in
elucidation of the endocrine role of pancreas in
metabolism and existence of insulin (Banting et al.,
1922).