A positive pH study on PPIs suggests that patients' persistent heartburn might be related to ongoing acid reflux (presence of abnormal pH suggest insufficient acid inhibition, whereas positive symptom indices with normal p suggest that heartburn is induced by normal levels of acid exposure) [32, 56, 59, 60]. A negative pH test on PPIs provides convincing evidence that the patients' symptoms are not related to ongoing acid reflux. However, a negative pH test on PPIs does not exclude the possibility of underlying reflux that may be a cofactor in patient's symptom and is being adequately suppressed on PPIs. As the poor tolerability of pH probes could result in a significant decrease in reflux provoking activities [61], the use of wireless pH capsule, that allows
A positive pH study on PPIs suggests that patients' persistent heartburn might be related to ongoing acid reflux (presence of abnormal pH suggest insufficient acid inhibition, whereas positive symptom indices with normal p suggest that heartburn is induced by normal levels of acid exposure) [32, 56, 59, 60]. A negative pH test on PPIs provides convincing evidence that the patients' symptoms are not related to ongoing acid reflux. However, a negative pH test on PPIs does not exclude the possibility of underlying reflux that may be a cofactor in patient's symptom and is being adequately suppressed on PPIs. As the poor tolerability of pH probes could result in a significant decrease in reflux provoking activities [61], the use of wireless pH capsule, that allows
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