In this contribution multicommutated flow analysis system developed for total protein determination in CSF samples has been presented. The system was integrated with highly economic and compact optoelectronic detectors designed for turbidimetric and nephelometric measurements. Both detection modes offered by optoelectronic device in the developed MCFA system are useful for CSF analysis, however at the same geometry of flow cell turbidimetric detection offers wider range of linear response and higher sensitivity. In the case of nephelometric mode of measurements lower detection limit is obtained allowing lower consumption (higher dilution) of CSF sample. The optimized flow analysis systems have been successfully validated with real human CSF samples.