This paper describes a novel regenerative braking control scheme of electric power-assisted wheelchairs for safety driving on downhill roads. The ldquoelectric power-assisted wheelchairrdquo which assists the driving force by electric motors is expected to be widely used as a mobility support system for elderly people and disabled people; however, it has no braking system to suppress the wheelchair's velocity and brings the dangerous and fearful driving particularly on downhill roads. Therefore, this paper proposes a novel safety and efficient driving control scheme based on the regenerative braking system. This paper applies the regenerative braking system with the step-up chopper circuit serially connecting two motors and realizes the velocity feedback control with the variable duty ratio so that it tracks the optimal velocity based on the minimum Jerk model. In addition, the dynamic braking system is also applied at the low-speed range instead of the regenerative braking in order to suppress the acceleration. Some driving experiments on the practical downhill roads show the effectiveness of the proposed control system.