Chalcopyrite is the major and most abundant commercialsource of copper [1]. It is often accompanied with pyrite, whichis the most widespread naturally occurring metal sulfides. The floatability of pyrite is quite similar to chalcopyrite [2,3]. Pyrite in copper concentrates will not only lower their quality but also increase the economic and environmental costs in the subsequent smelting process [4]. The collecting ability of traditional sulfides collectors is very strong but their selectivity is poor; thus, usually the ideal copper–sulfur separation couldnot be realized by these collectors. The copper released from chalcopyrite will activate pyrite and increase the difficulty forthe separation of chalcopyrite and pyrite as well [5,6]. Thereare five common copper–sulfur separation processes, whichare known as high pH process, inorganic inhibitors process,organic inhibitors process, electrochemical controlling pro-cess and cyanide process [7]. High pH value process is themost widely used process [8,9]. Even though this process couldget prefect flotation and separation result, a large amount oflime must be consumed and the recovery and grade of copper