The pathophysiology of uremic pruritus is poorly understood. Hypotheses implicating immunologic and opioidergic systems have been proposed [12].
Immunohypothesis — The immunohypothesis proposes that uremic pruritus is the result of systemic inflammation rather than a local skin disorder [13,14]. Immunomodulating therapies such as ultraviolet B (UVB) phototherapy, thalidomide, and calcineurin inhibitors have been shown to decrease uremic pruritus in some studies