Neuropathy Vincristine and, to a lesser extent, vinblastine can cause various neurotoxic effects. Nursing interventions for management of these effects include administering stool softeners or laxatives for severe constipation caused by decreased bowel innervation maintaining good body alignment and if patient is on bed rest, using a footboard or high-top shoes to minimize or prevent footboard carrying out safety measures during ambulation because of weakness and numbing of the extremities, which may cause difficulty in walking or fine hand movement and providing a soft or liquid diet for severe jaw pain.