Polysaccharides are a kind of macromolecules exist widely innature, which are considered as an important class of bioactivenatural products with specific bioactivities, such as immunostim-ulating, antioxidant, antiviral and anti-diabetic activities .Nowadays, lots of literatures have reported that the polysaccha-rides from Ganoderma atrum ,Lycium barbarum , Astragalus and so on, have anti-hyperglycemic or anti-hyperlipidemic activities.